RPL32 Promotes Lung Cancer Progression by Facilitating p53 Degradation
نویسندگان
چکیده
منابع مشابه
Pirh2, a p53-Induced Ubiquitin-Protein Ligase, Promotes p53 Degradation
The p53 tumor suppressor exerts anti-proliferative effects in response to various types of stress including DNA damage and abnormal proliferative signals. Tight regulation of p53 is essential for maintaining normal cell growth and this occurs primarily through posttranslational modifications of p53. Here, we describe Pirh2, a gene regulated by p53 that encodes a RING-H2 domain-containing protei...
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ژورنال
عنوان ژورنال: Molecular Therapy - Nucleic Acids
سال: 2020
ISSN: 2162-2531
DOI: 10.1016/j.omtn.2020.05.019